A facile chemoenzymatic route to optically pure building blocks for cyclopentanoid natural products
- 1 January 1986
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 16,p. 1298-1299
- https://doi.org/10.1039/c39860001298
Abstract
Compound (1R,4S)-(4a), a central chiral building block for cyclopentanoid natural products, was prepared in high yield and optically pure by enantioselective hydrolysis of (5a) in the presence of several lipases, and was further transformed into (R)-(1a), (1R,5S)-(2)-and (1S,5R)-(2), (7), and (8), important synthons for this class of compounds.Keywords
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