Human Papillomavirus Structural Antigens in Squamous Papillomas of the Male Urethra

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Abstract
Squamous papillomas (25) of the male urethra were examined for the presence of human papillomavirus (HPV) whole (structural) virion antigens by a peroxidase-antiperoxidase technique having immunospecificity against genus-specific (common) antigens of the papillomavirus genus. Eleven of 25 (44%) lesions were positive for HPV. The positive reaction was invariably intranuclear in the superficial epithelium. These papillomas apparently arise by HPV infection of metaplastic squamous epithelium and not transitional epithelium. This study shows that at least some squamous papillomas of the male urethra are associated with HPV infections, and suggests that this lesion may play an important role in venereally transmitted diseases such as cervical dysplasia and condylomas of the vulva and anus.

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