Effect of enalaprilat on bradykinin and des‐Arg9‐bradykinin release following reperfusion of the ischaemic rat heart
Open Access
- 1 June 1995
- journal article
- research article
- Published by Wiley in British Journal of Pharmacology
- Vol. 115 (3) , 476-478
- https://doi.org/10.1111/j.1476-5381.1995.tb16357.x
Abstract
1 The release of bradykinin (BK) and its metabolite, des‐Arg9‐bradykinin (des‐Arg9‐BK), was studied following reperfusion of a globally ischaemic rat heart. 2 BK‐like immunoreactivity increased from 13±3 (preischaemic value) to 48±12 fmol min−1 g−1 (Pn = 14) 30 s after reperfusion. No difference in BK release was found between control hearts and hearts pretreated with the angiotensin converting enzyme (ACE or kininase II) inhibitor, enalaprilat (50 ng ml−1). 3 No significant change in des‐Arg9‐BK‐like immunoreactivity during reperfusion was observed in control hearts. In contrast, des‐Arg9 ‐ BK ‐ like immunoreactivity rose from 44 ± 15 to 177 ± 61 fmol min−1 g−1 (P9‐BK.Keywords
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