Imaging and kinetics studies with radiolabelled autologous low-density lipoproteins (LDL) in human atherosclerosis
- 1 October 1988
- journal article
- editorial
- Published by Wolters Kluwer Health in Nuclear Medicine Communications
- Vol. 9 (10) , 859-866
- https://doi.org/10.1097/00006231-198810000-00027
Abstract
Experimental data in rabbits show a significantly (P < 0.01) increased vascular uptake of autologous 125I-radiolabelled low-density lipoproteins (LDL) at various time intervals after experimental lesioning. In some vascular areas in patients, a positive gamma-camera image can be obtained as early as 30 min after reinjection of autologous 123I-labelled LDL only. Monitoring of kinetics provides reliable information on localized increased LDL entry in certain vascular areas. Although a number of methodological improvements are needed, the technique described may be of clinical value in the future.Keywords
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