Abstract
The effect of 1000 mg of tetracycline hydrochloride and 200 mg of minocycline hydrochloride on P. acnes levels and skin-surface lipid levels was measured in 15 patients with acne. Minocycline produced a significantly greater reduction in the P. acnes counts that persisted even up to 3 wk after discontinuation of the minocycline therapy, in contrast to the return of P. acnes to baseline counts within 3 wk after discontinuation of the tetracycline therapy. A similar persistence of effect for reduction of skin-surface free fatty acid levels and clinical lesions was also seen with minocycline therapy.

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