Failure of leucine to stimulate protein synthesis in vivo
- 15 June 1982
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 204 (3) , 831-838
- https://doi.org/10.1042/bj2040831
Abstract
The effect of 100.mu.mol of leucine on protein synthesis in several tissues was assessed in the intact rat. Leucine had no immediate effect on protein synthesis in gastrocnemius muscle, heart, jejunal serosa, jejunal mucosa or liver in rats which were fed, starved for 2 days or deprived of dietary protein for 9 days. Leucine treatment for 1 h also failed to stimulate protein synthesis in tissues of 2-day-starved animals.This publication has 31 references indexed in Scilit:
- Nitrogen sparing induced by leucine compared with that induced by its keto analogue, alpha-ketoisocaproate, in fasting obese man.Journal of Clinical Investigation, 1981
- The regulation of protein synthesis in mammalian cells by amino acid supplyBioscience Reports, 1981
- The role of alanine in the nitrogen conserving quality of the branched-chain amino acids in the postinjury stateJournal of Surgical Research, 1980
- Infusion of the Branched Chain Amino Acids in Postoperative Patients Anticatabolic PropertiesAnnals of Surgery, 1979
- Influence of amino acid availability on protein turnover in perfused skeletal muscleBiochimica et Biophysica Acta (BBA) - General Subjects, 1978
- Effect of Starvation on the Turnover and Metabolic Response to LeucineJournal of Clinical Investigation, 1978
- Nitrogen sparing induced early in starvation by infusion of branched-chain ketoacidsMetabolism, 1977
- The effect of protein deprivation and starvation on the rate of protein synthesis in tissues of the ratBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1975
- Leucine. A possible regulator of protein turnover in muscle.Journal of Clinical Investigation, 1975
- Some Special Kinetic Problems of TransportPublished by Wiley ,1969