Resistance to Trypanosoma brucei in Mice Following Inoculation of NTG-Treated Trypanosomes
- 1 September 1981
- journal article
- research article
- Published by American Society of Tropical Medicine and Hygiene in The American Journal of Tropical Medicine and Hygiene
- Vol. 30 (5) , 952-954
- https://doi.org/10.4269/ajtmh.1981.30.952
Abstract
The alkylating agent N-methyl-N′-nitro-N-nitrosoguanidine (NTG) was tested as an attenuating agent for Trypanosoma brucei. Parasites were treated with 4 mcg/ml NTG and injected into mice at intervals of 7–14 days. Those mice surviving four injections of NTG-treated trypanosomes were later challenged and showed a 100% resistance to infection. A corresponding group of control mice showed a 6% resistance to infection.This publication has 1 reference indexed in Scilit:
- Isolation and Characterization of a new Serodeme of Trypanosoma Rhodesiense *The American Journal of Tropical Medicine and Hygiene, 1979