STUDIES ON THE EFFECTS OF IRRADIATION OF CELLULAR PARTICULATES . II. THE EFFECT OF GAMMA RADIATION ON OXYGEN UPTAKE AND PHOSPHORYLATION
Open Access
- 1 August 1957
- journal article
- research article
- Published by University of Chicago Press in The Biological Bulletin
- Vol. 113 (1) , 198-206
- https://doi.org/10.2307/1538813
Abstract
Mitochondria were isolated from rat liver and exposed to gamma radiation. Cytochrome oxidase activity was depressed by doses of radiation ranging from 2,500 r up. Phosphorylation resulting from the oxidation of succinate was depressed by doses ranging from 2500 r. The phosphorylation mechanism is much more sensitive to gamma radiation than cytochrome oxidase. It is suggested that the utilization of substrates by enzymes within the particulate may protect these enzymes against ionizing radiation.This publication has 7 references indexed in Scilit:
- STUDIES ON THE EFFECTS OF IRRADIATION OF CELLULAR PARTICULATES. I. INHIBITION OF CYTOCHROME OXIDASE BY ULTRAVIOLETThe Biological Bulletin, 1956
- PHOSPHORYLATION COUPLED WITH THE OXIDATION OF REDUCED CYTOCHROME cJournal of Biological Chemistry, 1954
- MEASUREMENT AND CONTROL OF SOME DIRECT AND INDIRECT EFFECTS OF X-RADIATIONGenetics, 1954
- Effect of X-Radiation upon Succinoxidase of Rat KidneyExperimental Biology and Medicine, 1951
- INTRACELLULAR DISTRIBUTION OF ENZYMES .3. THE OXIDATION OF OCTANOIC ACID BY RAT LIVER FRACTIONS1948
- THE DISTRIBUTION OF CYTOCHROME OXIDASE AND SUCCINOXIDASE IN THE CYTOPLASM OF THE MAMMALIAN LIVER CELLJournal of Biological Chemistry, 1946
- The effect of X-rays on enzymesBiochemical Journal, 1940