Coupling of computer modeling with in vitro methodologies to reduce animal usage in toxicity testing
- 31 May 1993
- journal article
- Published by Elsevier in Toxicology Letters
- Vol. 68 (1-2) , 101-117
- https://doi.org/10.1016/0378-4274(93)90123-f
Abstract
No abstract availableKeywords
This publication has 13 references indexed in Scilit:
- Polychlorotrifluoroethylene (PCTFE) oligomer pharmacokinetics in Fischer 344 rats: Development of a physiologically based model*1, *2Fundamental and Applied Toxicology, 1992
- Physiologically based pharmacokinetic modeling with dichloromethane, its metabolite, carbon monoxide, and blood carboxyhemoglobin in rats and humansToxicology and Applied Pharmacology, 1991
- Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspectsChemical Research in Toxicology, 1991
- Physiologically based pharmacokinetic and pharmacodynamic model for the inhibition of acetylcholinesterase by diisopropyfluorophosphateToxicology and Applied Pharmacology, 1990
- Improving toxicology testing protocols using computer simulationsToxicology Letters, 1989
- A computer-assisted procedure for the assembly and analysis of short-term genotoxicity test dataToxicology Letters, 1989
- Biologically Motivated Models for Chemical Risk AssessmentHealth Physics, 1989
- In vitro metabolism of methylene chloride in human and animal tissues: Use in physiologically based pharmacokinetic modelsToxicology and Applied Pharmacology, 1989
- Physiologically based pharmacokinetics and the risk assessment process for methylene chlorideToxicology and Applied Pharmacology, 1987
- Risk Assessment Extrapolations and Physiological ModelingToxicology and Industrial Health, 1985