Haemolysis in Chronic Renal Failure

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Abstract
In a group of patients with a range of degree of advancement of renal failure, the red cell survival estimated as the half-life of 51Cr-labeled red blood cells (T1/2. 51CR) was correlated with several indices of renal failure. The T1/2. 51Cr was not improved by a dialysis program which was otherwise adequate. The correlation of a T1/2. 51Cr to the biochemical indices of renal failure was lost which might suggest that some other factor or factors than those measured was the ultimate correlate with red cell survival. Apparently, a guanidine or a similarly behaving molecule is the hemolyzing agent. A methionine-rich diet may inhibit the hemolytic factor.

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