Anti‐HBe and Subtypes of HBsAg among Asymptomatic HBsAg Carriers

Abstract
Finnish HBsAg [hepatitis B surface antigen] positive blood donors were analyzed for the HBsAg subtype distribution and the presence of e antigen (HBeAg) and antibody to e (anti-HBe). Of the donors, 159 of 180 (88%) had subtype ad and 12% (21 of 180) had ay. HBeAg was found in 1% (2 of 180) and anti-HBe in 74% (133 of 180) of the donors. Anti-HBe was significantly (P < 0.0001) more common among donors with subtype ad than with ay: 80 and 29%, respectively. The mean age of donors with both subtype ad and anti-HBe was significantly (P < 0.001) lower than that of the other donor categories.