Local application of growth-factor IGF-1 to healing bone Experiments with a titanium chamber in rabbits
- 1 January 1989
- journal article
- research article
- Published by Medical Journals Sweden AB in Acta Orthopaedica
- Vol. 60 (5) , 607-610
- https://doi.org/10.3109/17453678909150132
Abstract
In order to study the effects of bone healing, insulin-like growth factor 1 (IGF-1) was continuously applied with a minipump to a healing bone callus located inside a titanium chamber in a rabbit tibia. After 2 weeks, 99mTc-MDP uptake and calcium content were measured. IGF-1 decreased 99mTc-MDP uptake, and thus the mineral turnover rate, but the amount of bone mineral was unchanged. Probably the normal endogenous production of IGF-1 is already optimal for healing in this model.Keywords
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