The effect of treatment of rats with pituitary growth hormone on the activities of some enzymes involved in fatty acid degradation and synthesis

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Abstract
Measurements have been made of the activities of acyl-CoA dehydrogenase, enoyl-CoA hydratase, [beta] -hydroxyacyl-CoA dehydrogenase and ketothiolase in the livers of rats treated for either 12 hr or 3 days with pituitary growth hormone. There was a significant increase in the activity of acyl-CoA dehydrogenase in rats treated with the hormone for 3 days. Measurements were also made of the lipogenic enzymes acetyl-CoA carboxylase and palmitate synthase in the livers of similarly treated animals. There was a depression of the activity of both enzymes after 12 hr. treatment and a further decline after 3 days. The results are discussed in relation to the known increase in the rate of fatty acid oxidation and inhibition of fatty acid synthesis in rats treated with growth hormone.