Kidney Transplantation in Uremic Children with Cystinosis

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Abstract
Cadaveric renal transplantations were performed on 10 children between the ages of 8.0-12.5 yr for uremia secondary to infantile cystinosis. Of these children 6 were doing well 6-62 mo. after-transplantation; 3 of the 4 other recipients required a 2nd graft and eventually died of uremia or fulminant viral encephalitis; the other lost her 1st graft due to accelerated acute rejection and is now on maintenance hemodialysis. No further systemic complications of cystinosis was observed in the patients with functioning grafts. Apparently kidney transplantation is the treatment of choice for uremic children with infantile cystinosis.