Effect of Ageing on Progesterone-Polyoxyethylene Glycol 6000 Dispersions. X – Ray Study

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Abstract
Progesterone solid dispersions in polyoxyéthylene glycol 6000 were prepared by fusion method in order to improve the progesterone wettability and solubility in aqueous body fluids. Its crystalline state after fusion was determined by radiocrystallography on the pure drug and on the solidified melts. It has been established that a slow cooling speed of the melt induced the stable polymorph emergence in the solidified melt (α form). Moreover, X-ray diffraction patterns investigation showed a good physical stability of the preparations after one year storage at room temperature.