Oligodeoxynucleotide analogs with 5′‐linked anthraquinone
- 5 June 1989
- journal article
- Published by Wiley in FEBS Letters
- Vol. 249 (2) , 213-218
- https://doi.org/10.1016/0014-5793(89)80626-x
Abstract
We report here the synthesis of novel 5′‐linked oligodeoxynucleotides, both normal phosphodiester and phosphorothioate analogs, in which a covalently attached group at the 5′‐terminus is an anthraquinone. These compounds represent a new class of antisense compounds in which the base sequence of the oligodeoxynucleotide serves to deliver a nuclease‐resistant reactive drug‐like molecule to a cellular target nucleic acid (mRNA or DNA).Keywords
This publication has 24 references indexed in Scilit:
- Phosphorothioate and normal oligodeoxyribonucleotides with 5′-linked acridine: characterization and preliminary kinetics of cellular uptakeGene, 1988
- Antimessenger oligodeoxyribonucleotides: an alternative to antisense RNA for artificial regulation of gene expression — a reviewGene, 1988
- Sequence-targeted photosensitized reactions in nucleic acids by oligo-.alpha.-deoxynucleotides and oligo-.beta.-deoxynucleotides covalently linked to proflavinBiochemistry, 1988
- Synthesis, molecular modeling, DNA binding, and antitumor properties of some substituted amidoanthraquinonesJournal of Medicinal Chemistry, 1988
- Delivery of c-myc Antisense Phosphorothioate Oligodeoxynucleotides to Hematopoietic Cells in Culture by Liposome Fusion: Specific Reduction in c-myc Protein Expression Correlates with Inhibition of Cell Growth and DNA SynthesisPublished by Springer Nature ,1988
- A c-myc antisense oligodeoxynucleotide inhibits entry into S phase but not progress from G0 to G1Nature, 1987
- Oligothymidylates Substitubs en Position 3’ Par un Derive De L'AcridineNucleosides, Nucleotides and Nucleic Acids, 1986
- Reactive oligonucleotide derivatives and sequence-specific modification of nucleic acidsBiochimie, 1985
- Characterization of sequence-specific oligodeoxyribonucleoside methylphosphonates and their interaction with rabbit globin mRNABiochemistry, 1985
- Complementary addressed reagents carrying EDTA‐Fe(II) groups for directed cleavage of single‐stranded nucleic acidsFEBS Letters, 1984