The polarisation of the anteroposterior axis inDrosophila
- 18 July 2003
- Vol. 25 (8) , 781-791
- https://doi.org/10.1002/bies.10309
Abstract
The polarisation of the embryonic anteroposterior (AP) axis requires the establishment of positional cues with spatial information, and often involves complex intercellular communications, cell adhesion and cell movement. Recent work on several fronts has begun to shed light on how the initial asymmetries are established and maintained. In this review, I discuss the polarisation of the AP axis during Drosophila oogenesis, focusing on the function of the Notch signalling pathway and its relationship to the activation of the epidermal growth factor receptor. I make special reference to some aspects of Notch activity regulation during oogenesis that appear to depart from the canonical pathway. Finally, I hypothesise on possible similarities between these activities of Notch signalling during Drosophila oogenesis and vertebrate somitogenesis. BioEssays 25:781–791, 2003.Keywords
This publication has 58 references indexed in Scilit:
- Variations on the Notch pathway in neural developmentCurrent Opinion in Neurobiology, 2002
- Drosophila oogenesis: Coordinating germ line and somaCurrent Biology, 2001
- Notch signaling in the nervous system. Pieces still missing from the puzzleBioEssays, 2000
- 1998 warkany lecture: Signaling pathways in developmentTeratology, 1999
- Notch Signaling: Cell Fate Control and Signal Integration in DevelopmentScience, 1999
- Versatility in signalling: multiple responses to EGF receptor activation during Drosophila oogenesisTrends in Cell Biology, 1999
- The Notch1 receptor is cleaved constitutively by a furin-like convertaseProceedings of the National Academy of Sciences, 1998
- LIN-12/Notch signaling: lessons from worms and fliesGenes & Development, 1998
- Intracellular Cleavage of Notch Leads to a Heterodimeric Receptor on the Plasma MembraneCell, 1997
- The origin of pattern and polarity in the Drosophila embryoCell, 1992