Thermographic Selection of Effective Catalysts from an Encoded Polymer-Bound Library
- 10 April 1998
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 280 (5361) , 267-270
- https://doi.org/10.1126/science.280.5361.267
Abstract
A general method is introduced for the rapid and simultaneous evaluation of each member of large encoded catalyst libraries for the ability to catalyze a reaction in solution. The procedure was used to select active catalysts from a library of potential polymer-bound multifunctional catalysts. From ∼7000 beads screened (3150 distinct catalysts), 23 beads were selected for catalysis of an acylation reaction. Kinetic experiments indicate that the most strongly selected beads are also the most efficient catalysts.Keywords
This publication has 11 references indexed in Scilit:
- Effective Kinetic Resolution of Secondary Alcohols with a Planar−Chiral Analogue of 4-(Dimethylamino)pyridine. Use of the Fe(C5Ph5) Group in Asymmetric CatalysisJournal of the American Chemical Society, 1997
- New Catalysts and Conditions for a C-H Insertion Reaction Identified by High Throughput Catalyst ScreeningAngewandte Chemie International Edition in English, 1996
- Infrared Thermographic Screening of Combinatorial Libraries of Heterogeneous CatalystsIndustrial & Engineering Chemistry Research, 1996
- Combinatorial Approach to the Discovery of Novel Coordination ComplexesJournal of the American Chemical Society, 1996
- Protein Structure-Based Combinatorial Chemistry: Discovery of Non-Peptide Binding Elements to Src SH3 DomainJournal of the American Chemical Society, 1996
- Phosphatase Catalysis Developed via Combinatorial Organic ChemistryThe Journal of Organic Chemistry, 1995
- Kinetics by thermometry: an aldol condensation reactionJournal of the Chemical Society, Faraday Transactions, 1995
- Tributylphosphine: a remarkable acylation catalystJournal of the American Chemical Society, 1993
- General method for rapid synthesis of multicomponent peptide mixturesInternational Journal of Peptide and Protein Research, 1991
- Heterocyclic polymers as catalysts in organic synthesis - effect of macromolecular design and microenvironment on the catalytic activity of polymer-supported (dialkylamino)pyridine catalystsMacromolecules, 1987