Flurandrenolone Lotions for Surface Depot Therapy. Detailed Assay and Clinical Studies

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Abstract
The use of total body inunction with the occlusive dressing, or surface depot technic, with flurandrenolone lotion, 0.05%, containing neomycin sulfate, 0.5%, shows no evidence, within the limits of the experiments, of any significant absorption of the corticosteriod or any visceral taxicity from the neomycin sulfate. In extensive clinical studies there was likewise no evidence of such absorption or of visceral toxicity. Moreover, in the studies limited to in-patients, there was no evidence of interference with temperature regulation by extensive dressings. In a large series of patients, occlusive dressings, or surface depot technics, with flurandrenolone lotion was more effective topical corticosteroid therapy than just inunction alone. Local reactions to such therapy were uncommon and included irritation from either the dressing or the lotion, and pustular folliculitis.