SUPPRESSION OF PROLACTIN AND GONADOTROPIN SECRETION IN POST-MENOPAUSAL WOMEN BY 2-HYDROXYESTRONE
- 1 February 1980
- journal article
- other
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 50 (2) , 408-410
- https://doi.org/10.1210/jcem-50-2-408
Abstract
An infusion of 2-hydroxyestrone given to estrogen primed post-menopausal women resulted in a rapid and total suppression of serum prolactin. Serum LH responded with an initial rise followed by a 30% decrease below baseline values. Serum FSH exhibited a significant suppression below preinfusion levels. The catechol estrogen had no effect on serum LH, FSH and PRL in post-menopausal women who were not pretreated with estrogens. This impact of 2-hydroxyestrone on pituitary hormone secretion provides for the physiological role of this non-uterotropic estrogen in the neuroendocrine mechanisms of the human.Keywords
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