An Approach to the Treatment of Vitiligo by Khellin
- 1 January 1982
- journal article
- research article
- Published by S. Karger AG in Dermatology
- Vol. 165 (2) , 136-140
- https://doi.org/10.1159/000249932
Abstract
An anticipated effect of khellin, related to its chemical structure, in the photochemotherapy of amelanosis has been investigated. In a double-blind clinical study, khellin has been orally administered to 30 vitiligo patients for 4 months with subsequent exposure to natural sunlight. At the end of the trial period. 5 patients out of 30 (16.6%) repigmented 90–100%; 7 cases (23.3%) repigmented 50–60% of the vitiliginous areas treated; 11 (36.6%) repigmented 25% or less, and 7 subjects (23.3%) showed negative response. 30 control subjects failed to repigment at all. The achieved repigmentation was stable after drug cessation for a period of 1 year. These data add a previously unreported effect for the non-psoralen compound, khellin, in the therapy of vitiligo.This publication has 3 references indexed in Scilit:
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