Synthesis and antitumor activity of sugar-ring hydroxyl analogs of daunorubicin

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Abstract
Daunorubicin analogs in which the natural amino sugar, daunosamine, is replaced by neutral 2,6-dideoxyhexopyranosyl residues have been prepared in high yields. Glycosidation of 3,4-di-O-acetyl-2,6-dideoxy-.alpha.-L-lyxo-hexopyranosyl chloride (13) with daunomycinone under Koenigs-Knorr conditions yielded exclusively the protected .alpha.-anomeric product 4, which was converted into the free glycoside 5 [3''-hydroxydaunorubicin]. In contrast, the 1-chloro-D-ribo isomer 19, bearing p-nitrobenzoyl groups for hydroxyl-group protection, furnished a 5:3 mixture of the .alpha. (6) and .beta. (7) glycosides. Separation and individual deprotection afforded the target compounds 8 (from 6) and 9 (from 7). Whereas all of the D-ribo analogues (6-9) are inactive as antitumor agents in vivo against P388 lymphocytic leukemia in mice, the protected L-lyxo glycoside 4 (T/C 186) and also the free glycoside 5 (T/C 183) are highly effective in this test system; 5 is also active (T/C 146) in vivo against murine B16 melanocarcinoma.

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