A Useful Method for the Synthesis of β-2′,3′-Dideoxynucleosides via a Thioglycoside
- 1 January 1992
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1992 (07) , 553-555
- https://doi.org/10.1055/s-1992-21411
Abstract
A series of the protected β-2′,3′-dideoxypyrimidine nucleosides are synthesized stereoselectively by the coupling of phenyl 5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-1-thio-D-glycero-pentofuranoside with silyl derivatives of nucleoside bases in the presence of N-bromosuccinimide at -78 °C.Keywords
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