Lack of Interaction Between Nizatidine and Warfarin During Chronic Administration
- 1 December 1988
- journal article
- research article
- Published by Wiley in The Journal of Clinical Pharmacology
- Vol. 28 (12) , 1120-1122
- https://doi.org/10.1002/j.1552-4604.1988.tb05727.x
Abstract
Nizatidine is a new antagonist of H2 receptors. The nizatidine warfarin interaction was investigated in healthy volunteers during chronic warfarin (mean warfarin dose: 5 ± 0.9 mg/d) and nizatidine (300 mg/d) administration. Nizatidine coadministration did not increase the prothrombin time, kaolin-cephalin clotting time, and did not modify the activity of clotting factors II, VII, IX, X. Nizatidine did not influence the steady-state plasma warfarin concentration.This publication has 10 references indexed in Scilit:
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