Biphasic Inhibition of Urokinase-Induced Fibrinolysis by isin-Aminocaproic Acid; Distinction from Tissue Plasminogen Activator

Publisher Website
Google Scholar
Abstract
Inhibition of porcine tissue plasminogen activator by ∊-aminocaproic acid (EACA), trans-4-aminomethylcyclohexancarboxylic acid (trans-AMCHA) and p-axmnomethylbenzoic acid (PAMBA) increased uniformly with increasing concentrations of inhibitor. In contrast, with human urokinase an early phase of inhibition at low inhibitor concentrations was followed by a phase of enhancement of fibrinolysis turning into a second phase of inhibition at inhibitor concentrations 300 times higher than required in the first phase. This biphasic inhibition of urokinase distinguishes it chemically from tissue plasminogen activator.

This publication has 0 references indexed in Scilit: