Hibernating Myocardium Retains Metabolic and Contractile Reserve Despite Regional Reductions in Flow, Function, and Oxygen Consumption at Rest
- 10 January 2003
- journal article
- research article
- Published by Wolters Kluwer Health in Circulation Research
- Vol. 92 (1) , 48-55
- https://doi.org/10.1161/01.res.0000049104.57549.03
Abstract
Hibernating myocardium, characterized by reductions in flow and function at rest, has limited contractile reserve in response to increases in external workload. We hypothesized that this attenuatio...Keywords
This publication has 13 references indexed in Scilit:
- Variability of contractile reserve in hibernating myocardium: dependence on the method of inotropic stimulation.Cardiovascular Research, 2002
- Stability of hibernating myocardium in pigs with a chronic left anterior descending coronary artery stenosis: absence of progressive fibrosis in the setting of stable reductions in flow, function and coronary flow reserveJournal of the American College of Cardiology, 2001
- Progressive loss of perfusion-contraction matching during sustained moderate ischemia in pigsAmerican Journal of Physiology-Heart and Circulatory Physiology, 2001
- Regional alterations in SR Ca2+-ATPase, phospholamban, and HSP-70 expression in chronic hibernating myocardiumAmerican Journal of Physiology-Heart and Circulatory Physiology, 1999
- Hibernating MyocardiumPhysiological Reviews, 1998
- Myocardial Cell Death and Apoptosis in Hibernating MyocardiumJournal of the American College of Cardiology, 1997
- Mechanisms of ?-adrenergic receptor desensitization: from molecular biology to heart failureBasic Research in Cardiology, 1996
- Adaptive responses of coronary circulation and myocardium to chronic reduction in perfusion pressure and flowAmerican Journal of Physiology-Heart and Circulatory Physiology, 1994
- Metabolic response to prolonged reduction of myocardial blood flow distal to a severe coronary artery stenosis.Circulation, 1988
- Sustained regional dysfunction produced by prolonged coronary stenosis: gradual recovery after reperfusion.Circulation, 1983