Benzotriazol-1-ylalkyl isocyanides: versatile synthons for preparation of unsymmetrical formamidines
- 1 January 1990
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 7,p. 1847-1851
- https://doi.org/10.1039/p19900001847
Abstract
Adducts from benzotriazole, an aldehyde, and formamide are dehydrated to α-(benzotriazol-1 -yl)alkyl isocyanides which readily add to secondary amines to form N′-(benzotriazol-1-ylalkyl)-N,N-dialkylformamidines. The benzotriazolyl group in the latter is displaced by Grignard reagents to yield the corresponding unsymmetrical formamidines.This publication has 1 reference indexed in Scilit:
- The chemistry of benzotriazole. Part 8. A novel two-step procedure for the N-alkylation of amidesJournal of the Chemical Society, Perkin Transactions 1, 1988