Nuclear Receptors: The Evolution of Diversity
- 27 January 2004
- journal article
- review article
- Published by American Association for the Advancement of Science (AAAS) in Science's STKE
- Vol. 2004 (217) , pe4
- https://doi.org/10.1126/stke.2172004pe4
Abstract
Nuclear receptors are an ancient family of transcription factors. Some receptors are regulated by small lipophilic ligands, whereas others are constitutive transcriptional activators or repressors. The evolution of this diversity is poorly understood, and it remains an open question as to whether or not the ancestral receptor was ligand-regulated. The recent cloning, from a snail, of an estrogen receptor that does not bind estrogen not only suggests that the steroid receptors are much more ancient than previous thought, but also points toward a mechanism through which nuclear receptors can lose the ability to be ligand regulated.Keywords
This publication has 27 references indexed in Scilit:
- Structural Basis for Ligand-Independent Activation of the Orphan Nuclear Receptor LRH-1Molecular Cell, 2003
- Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptorsNature, 2003
- X-Ray Structure of the hRORα LBD at 1.63 ÅStructure, 2002
- A estradiol‐17β receptor in the reproductive system of the female of Octopus vulgaris: Characterization and immunolocalizationMolecular Reproduction and Development, 2002
- Crystal Structure of the Ligand-binding Domain of the Ultraspiracle Protein USP, the Ortholog of Retinoid X Receptors in InsectsPublished by Elsevier ,2001
- Ligand binding and nuclear receptor evolutionBioEssays, 2000
- Ligand-induced stabilization of PPARγ monitored by NMR spectroscopy: implications for nuclear receptor activationJournal of Molecular Biology, 2000
- Catalytic promiscuity and the evolution of new enzymatic activitiesChemistry & Biology, 1999
- SXR, a novel steroid and xenobioticsensing nuclear receptorGenes & Development, 1998
- ENZYME RECRUITMENT IN EVOLUTION OF NEW FUNCTIONAnnual Review of Microbiology, 1976