Toxicity of Para-Chloro Substituted Benzene Derivatives in the Microtox™ Test

1 May 1985

journal article
Published by IWA Publishing in Water Quality Research Journal

Vol. 20 (2) , 36-43
https://doi.org/10.2166/wqrj.1985.016

Abstract

This paper gives the results of part of a systematic investigation into contaminant toxicity to Photobacterium phosphoreum in the Microtox™ test. Reported are the toxicity values for 39 para-chloro substituted benzene derivatives of the general formula l-Cl-C₆h₄-4-X=CH₂CH(NH₂)COOH, F, SO₂NH₂, OCH₂COOH, CH₂COOH, CONHNH₂, NHCOCH₃, CONH₂, CH=CHCOOH, SeOOH, CH₂NH₂, CH₂CH₂NH₂, NO₂, H, CF₃, CHO, CH₂OH, OH, CH₃, CCl₃, COCH₃, COOH, NH₂, SO₂C₆H₅, Cl, CH₂COCH₃, COCl, CN, OCH₃, NCO, NHCH₃, I, COC₆H₅, CH₂Cl, SH, CH₂SH, NCS, CH₂CN and SO₂C₆H₄Cl. Except for the last compound, whose solubility is below the required concentration, the toxicities increase in the presented order with a total range of more than three orders of magnitude. The data are discussed in terms of quantitative structure-toxicity correlations with compound-specific structural parameters. In combination with a previously developed submodel on chlorinated benzenes, phenols, nitrobenzenes and anilines, the observed relationships allow the prediction of the toxicity of some 780 possible chloro derivatives of the general formula C₆H_5-nCl_nX, where n=<5 and X is a functional group as listed above.

Keywords

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