Immunodeficiency in Protein Kinase Cβ-Deficient Mice
- 9 August 1996
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 273 (5276) , 788-791
- https://doi.org/10.1126/science.273.5276.788
Abstract
Cross-linking of the antigen receptor on lymphocytes by antigens or antibodies to the receptor results in activation of enzymes of the protein kinase C (PKC) family. Mice homozygous for a targeted disruption of the gene encoding the PKC-βI and PKC-βII isoforms develop an immunodeficiency characterized by impaired humoral immune responses and reduced cellular responses of B cells, which is similar to X-linked immunodeficiency in mice. Thus PKC-βI and PKC-βII play an important role in B cell activation and may be functionally linked to Bruton's tyrosine kinase in antigen receptor-mediated signal transduction.Keywords
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