IMPACT OF ACUTE REJECTION AND EARLY ALLOGRAFT FUNCTION ON RENAL ALLOGRAFT SURVIVAL

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Abstract
Both acute rejection and the function of a renal allograft early after transplantation correlate with long-term graft survival. In this study we assessed the relationship between these two factors in 843 adult recipients of first cadaveric renal grafts, transplanted at a single institution and followed for a minimum of 3.5 years. Patients were divided into four groups according to (1) history of acute rejection (AR) during the first 6 months after transplantation, and (2) concentration of serum creatinine at 6 months after transplantation (SCr6mo 6mo (group 1, n=376), patients without AR but with an elevated SCr6mo (group 2, n=117), and patients with AR but low SCr6mo (group 3, n=185). In contrast, graft survival was significantly worse in patients with AR and an elevated SCr6mo (group 4, n=165) compared with patients in the other three groups (Cox,