Über eine neue Methode zur positionsselektiven Einführung von Trifluormethyl-Gruppen in Heteroaromaten, Teil 2.1Nucleophile Substitution an 5-fluor-4-trifluormethyl-substituierten 1,3-Azolen
- 1 January 1988
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1988 (03) , 194-198
- https://doi.org/10.1055/s-1988-27510
Abstract
A New Method for Regioselective Introduction of Trifluoromethyl Groups into Heteroarenes; Part2. Nucleophilic Substitution of 5-Fluoro-4- trifluoromethyl-1,3-azoles 5-Fluoro-4-trifluoromethyl-1,3-azoles are readily susceptible to nucleophilic displacement reactions at C-5. With binucleophiles, the reactioncan be used for linking trifluoromethyl-substituted 1,3-azoles to aromatic, heteroaromatic, and heterocyclic systems, linearly or angularly,directly or across various bridging groups respectively.Keywords
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