Delay of development of responses to ethanol in mice: associated delay in another parameter.

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Abstract
The pattern of response development to alcohol was observed and compared with the total fluid intake (TFI)/g of body weight, using the same method of determining preference or aversion to the alcohol solution as in a previous study. In the 1st exploratory study, 39 CF1 male mice were studied at 52 wk of age; the 26 mice averse to alcohol (i.e., drank less than 30% of their TFI as alcohol solution) had a significantly greater mean body weight and significantly smaller TFI/g of body weight than the nonaverse group. Mean TFI did not differ between the 2 groups. In the 2nd study 22 CF1 male mice were studied from 6-50 wk of age; by 50 wk only 8 mice were drinking less than 30% of their TFI as alcohol. The mean body weights of the 8 did not differ from the remainder; their mean TFI at 25, 35 and 50 wk was significantly lower than in the others and TFI/g of body weight became also significantly lower by 25 wk. A 4 wk study of 24 CF1 male mice in which half of the animals received only water and the other half only the 3% alcohol solution indicated no differences between groups in TFI or body weight. In a final study of 23 C3H male mice not previously exposed to alcohol, a 2 wk water control study was begun at age 52 wk, followed by a 4 wk study of their responses to a 3% alcohol solution offered as an alternative to water. The mice that were not averse to alcohol at this age had a significantly higher TFI/g of body weight during the initial water control study prior to exposure to alcohol than did mice demonstrating aversive behavior to alcohol. Mice showing a delay in developing an aversive response to alcohol also show a higher TFI/g of body weight which is not related to alcohol consumption per se.

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