Lysosomal abnormalities in cultured schwann cells from a patient with peripheral neuropathy and continuous muscle fiber activity

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Abstract
Schwann cell cultures were established from a sural nerve containing large membrane‐bound vaculoes in its schwann cells, obtained from a patient with neuropathy and continuous muscle fiber activity. cultured Schwann cell contained may large membrane‐bound vaculoles, presumably lysosomes, resembling those present in the biopsied nerve. the acid phosphatase reaction was excessive in the patient's cultured schwann cells but practically negative in normal cultured Schwann cells. this study Indicates that the patient's neuropathy is primary dysschwannian with abnormal lysosomes as a major abnormality.

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