Cefadroxil treatment of infections of the ears, nose and throat

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Abstract
The efficacy and tolerance of the new oral cephalosporin cefadroxil was tested in 65 patients (39 men and 26 women) treated for a large variety of moderate to severe infections of the ears, nose and throat which were not expected to undergo a spontaneous remission. The most frequently isolated pathogens were streptococci and Staphylococcus aureus. Patients received doses of 1 g every 12 h and the treatment lasted between 2 and 24 days with an average of 8·8 days. In 35 patients, some of whom had already been treated unsuccessfully with another antibiotic, the results were very good; they were good in 24; and not evaluable or unsatisfactory in 6 patients with resistant bacteria, such as Pseudomonas, or who needed surgical intervention. A high degree of effectiveness and a rapid response to treatment with cefadroxil were impressive. No relapses were recorded. Clinical examination of the 65 patients revealed one case of allergic skin reaction in a patient who was allergic to guinea pig's and lamb's hair. Four patients complained of transient nausea, two of diarrhoea, and one each of anorexia or vertigo after having taken the drug on an empty stomach. Seven patients who had a clinical history of gastrointestinal diseases did not report any adverse symptoms. Cefadroxil thus proved to be an effective and well-tolerated antibiotic.

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