Inhibition of Charonia lampas Ascorbate-2-sulfate Sulfohydrolase Activity by Adenosine 5'-Diphosphate and Related Compounds1
- 1 April 1975
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Biochemistry
- Vol. 77 (4) , 807-810
- https://doi.org/10.1093/oxfordjournals.jbchem.a130786
Abstract
ADP was a potent inhibitor of the ascorbate-2-sulfate sulfohydrolase activity of Charonia lampas liver. The inhibition was competitive with respect to ascorbate 2-sulfate. The K1 value was 5.9 μM. ADP did not inhibit arylsulfatase [EC 3.1. 6.1] of the same organism. Other nucleoside 5′-diphosphates and GTP showed similar inhibition of ascorbate-2-sulfate sulfohydrolase activity. The effects of different nucleosides, nucleotides, and sugar phosphates on ascorbate-2-sulfate sulfohydrolase activity were investigated. Phosphate derivatives other than 3′, 5′-cyclic AMP were more or less inhibitoryKeywords
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