Marfan syndrome is closely linked to a marker on chromosome 15q1.5----q2.1.
- 15 May 1991
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 88 (10) , 4486-4488
- https://doi.org/10.1073/pnas.88.10.4486
Abstract
Marfan syndrome is a systemic disorder of the connective tissue inherited as an autosomal dominant trait. The disorder imparts significant morbidity and mortality. The etiology of the disorder remains elusive. A recent study localized the gene for Marfan syndrome on chromosome 15. We present data showing that marker D15S48 is genetically linked to Marfan syndrome. Pairwise linkage analysis gave a maximum lod (logarithm of odds) score of Z = 11.78 at theta = 0.02. Furthermore our data suggest that the Marfan syndrome locus is possibly flanked on either side by D15S48 and D15S49.Keywords
This publication has 25 references indexed in Scilit:
- Deficient expression of the gene coding for decorin in a lethal form of Marfan syndrome.Journal of Biological Chemistry, 1990
- Immunohistologic Abnormalities of the Microfibrillar-Fiber System in the Marfan SyndromeNew England Journal of Medicine, 1990
- Linkage analysis in Marfan syndrome.Journal of Medical Genetics, 1990
- Marfan syndrome. Demonstration of abnormal elastin in aorta.Journal of Clinical Investigation, 1982
- Studies on elastic tissue of aorta in aortic dissections and Marfan syndrome.1981
- Cell-free synthesis of hyaluronic acid in Marfan syndrome.Journal of Biological Chemistry, 1979
- The Marfan Syndrome: Diagnosis and ManagementNew England Journal of Medicine, 1979
- Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase IJournal of Molecular Biology, 1977
- Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies.1974
- Life Expectancy and Causes of Death in the Marfan SyndromeNew England Journal of Medicine, 1972