The Development and Prognosis of Chronic Intoxication by Tetrachlordibenzo-p-dioxin in Men

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Abstract
During 1965-1968, 80 workers engaged in the production of 2,4,5-sodium trichlorphenoxyacetate and butylester of trichlorphenoxyacetate acid became ill. The cause of the illness was 2,4,7,8-tetrachlordibenzo-p-dioxin. A 10 yr study was conducted for 55 exposed individuals. The majority of the patients developed chloracne, and 11 manifested porphyria cutanea tarda. Approximately 1/2 of the patients suffered from metabolic disturbances (pathologically elevated lipids with abnormalities in the lipoprotein spectrum), 2/5 had pathological changes in the glucose tolerance test and 1/3 had biochemical deviations indicative of a mild liver lesion. Histological examination revealed light steatosis, periportal fibrosis or activation of Kupffer cells. Fluorescence of the liver tissues was present in UV light. In 17 persons symptoms of nervous system focal damage existed, with predominance of peripheral neuron lesion of the lower extremities (verified by electromyographic examination). The majority of patients suffered from various psychological disorders. Two patients died of bronchogenic lung carcinoma; one of liver cirrhosis, one of a rapidly developed, extremely unusual type of atherosclerosis precipue cerebri, and 2 others died in traffic accidents. The conditions of most other patients improved.

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