Effect of experimental subarachnoid hemorrhage on the adrenergic innervation of cerebral arteries

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Abstract
The effect of subarachnoid hemorrhage (SAH) on the adrenergic innervation of cat cerebral arteries was analyzed. Intracisternal injections of autologous blood reduced the noradrenaline [norepinephrine] content from the perivascular nerves. Dopamine .beta.-hydroxylase and the uptake of 3H-noradrenaline were decreased. These changes returned to normal in a period 2-3 wk after the SAH. Superior cervical ganglionectomy and intracisternal injections of 6-hydroxydopamine reduced these 3 parameters. SAH may induce a transient adrenergic denervation of the cerebral arteries which may be involved in the production of the chronic cerebral vasospasm.