The Effect of Estrogenic Hormones on Cell Division and Growth in Some Tissues of Mice

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Abstract
— The effect of estrogens upon cell division in genital and non‐genital tissues of mice has been investigated, the non‐genital tissue in vivo as well as in vitro, the genital tissue in vivo. In the in vivo experiments an increased mitotic index depending upon an increased prophase number was observed, from what it may be concluded that there is a real mitotic activation. In the in vitro experiments it was observed that the effect of estradiol upon cell division depended upon the concentration in the medium: Low concentration caused increased mitotic activity, high concentrations, on the other hand, caused a metaphase block. A difference in response to estrogens of genital and non‐genital tissue as well as a different effect upon tissue in vivo and in vitro have been observed.