CELLS WITH FC-GAMMA RECEPTORS FROM NORMAL DONORS SUPPRESS GRANULOCYTIC MACROPHAGE COLONY FORMATION

  • 1 January 1982
    • journal article
    • research article
    • Vol. 60  (3) , 758-766
Abstract
The role of normal human marrow cells with Fc receptors for IgG (Fc.gamma.+) on autologous granulocyte-macrophage colony (GM-CFC) formation was investigated. Fc.gamma.+ normal human marrow cells, both with (E+) or without receptors for sheep erythrocytes suppressed GM-CFC at as low a concentration as 0.25 .times. 106 cells/ml of culture. A similar effect was observed with E- Fc.gamma.+ but not E+ Fc.gamma.+ peripheral blood cells. Suppression by Fc.gamma.+ cells did not require mitogen activation and was not inactivated by irradiation (2000 R). A new in vitro regulatory mechanism for GM-CFC growth in normal donors is presented.