Molecular interactions of caffeine with o-, m- and p-iodobenzoic acids and o-, m- and p-fluorobenzoic acids
- 1 August 1967
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 19 (8) , 495-501
- https://doi.org/10.1111/j.2042-7158.1967.tb09578.x
Abstract
The solubilities of o-, m- and p-iodo- and fluorobenzoic acids in aqueous solutions of caffeine increase linearly with caffeine concentration due to complex-formation. Insoluble complexes are formed by the o- and m-acids and soluble ones by the p-acids. Approximate 1:1 stability constants have been evaluated from the phase diagrams and their values are considered in relation to possible mechanisms of complex-formation.Keywords
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