The use of levamisole in atopic dermatitis: a prospective study

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Abstract
Levamisole hydrochloride, a nonspecific immunostimulant, was given to 30 children with atopic dermatitis (AD) in a double-blind manner during an 8-mo. period. Clinical course findings, including intradermal reactions to tuberculin, candidin, and streptokinase-streptodornase; sensitization to dinitrochlorobenzene; peripheral blood T[thymus derived]- and B[bone marrow derived]- lymphocytes; in vitro lymphocyte transformation with phytohemagglutinin; and serum levels of Ig[immunoglobulin]M, IgG, IgA, and IgE, were noted every 2 mo. Fifteen children completed the study. Neither the clinical course nor the immunologic values showed substantial differences between the levamisole-treated and the placebo group.