Comparative assessment of large-scale data sets of protein–protein interactions
Top Cited Papers
- 8 May 2002
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 417 (6887) , 399-403
- https://doi.org/10.1038/nature750
Abstract
Comprehensive protein–protein interaction maps promise to reveal many aspects of the complex regulatory network underlying cellular function. Recently, large-scale approaches have predicted many new protein interactions in yeast. To measure their accuracy and potential as well as to identify biases, strengths and weaknesses, we compare the methods with each other and with a reference set of previously reported protein interactions.Keywords
This publication has 44 references indexed in Scilit:
- Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometryNature, 2002
- Functional organization of the yeast proteome by systematic analysis of protein complexesNature, 2002
- Predictome: a database of putative functional links between proteinsNucleic Acids Research, 2002
- Is There a Bias in Proteome Research?Genome Research, 2001
- Global Analysis of Protein Activities Using Proteome ChipsScience, 2001
- A comprehensive two-hybrid analysis to explore the yeast protein interactomeProceedings of the National Academy of Sciences, 2001
- Towards an understanding of complex protein networksTrends in Cell Biology, 2001
- Detecting Protein Function and Protein-Protein Interactions from Genome SequencesScience, 1999
- From Genome to Proteome: Looking at a Cell's ProteinsScience, 1995
- A novel genetic system to detect protein–protein interactionsNature, 1989