A model for biological oscillations.
- 1 April 1981
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 78 (4) , 2204-2207
- https://doi.org/10.1073/pnas.78.4.2204
Abstract
A model and computation for oscillatory phenomena observed in some biological processes that use ion gradients across a membrane is presented. The model contains 2 main features: active H+ transport pathways in the membrane, and key enzymes having a pH-dependent activity profile and either translocating H+ from outside or producing H+ as a product. With this model a very long period of oscillations, as observed in mitochondrial and circadian rhythms, was quantitatively demonstrated.This publication has 13 references indexed in Scilit:
- Proton transport across charged membrane and pH oscillationsBiophysical Journal, 1980
- pH oscillations in transport processtJournal of Theoretical Biology, 1979
- On the functional proton current pathway of electron transport phosphorylationBiochimica et Biophysica Acta (BBA) - Reviews on Bioenergetics, 1979
- A Timekeeping Enzyme in the Pineal GlandScientific American, 1979
- Electron Transfer Pathways, Mechanisms, and ControlsAnnual Review of Biochemistry, 1977
- Proton translocation reactions in the respiratory chainsBiochimica et Biophysica Acta (BBA) - Reviews on Bioenergetics, 1976
- A biochemical model of the circadian clockJournal of Theoretical Biology, 1975
- Membrane model for the circadian clockNature, 1974
- Daily Rhythm of Luciferin Activity in Gonyaulax polyedraScience, 1963
- Coupling of Phosphorylation to Electron and Hydrogen Transfer by a Chemi-Osmotic type of MechanismNature, 1961