Re: Dietary Fat Reduction and Breast Cancer Outcome: Interim Efficacy Results From the Women's Intervention Nutrition Study

Abstract
Chleblowski et al. ( 1 ) recently reported an interim analysis of the Women's Intervention Nutrition Study trial and concluded that a reduction in dietary fat intake may influence relapse-free survival following breast cancer. This effect was observed mainly in the subgroup of patients with previously diagnosed hormone receptor–negative tumors. The accompanying Editorial ( 2 ) noted that the study's conclusion is contrary to much of the literature and raised the possibility that the analysis may have been confounded by either the higher frequency of mastectomy or greater weight loss in the intervention group.

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