Enhanced Hepatic Chromatin Protein Methylation Induced by Triiodothyronine Treatment of the Rat
- 1 January 1980
- journal article
- research article
- Published by Taylor & Francis in Endocrine Research Communications
- Vol. 7 (2) , 113-119
- https://doi.org/10.1080/07435808009065965
Abstract
A pharmacological dose of 3,3′,5-triiodo-L-tbyronine (200 μg/100g) that induces marked DNA replication in rat liver cells, also is shown to cause a significant increase in the methylation of chromatin proteins in these cells. This increase in the methylation appears to correlate with the increase in DNA replication. Specificity of this phenomenon is suggested by its absence in kidney and spleen of the hormone-treated animals, two tissues that also fail to respond proliferatively to the iodothyronine.Keywords
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