MIF proteins are not glutathione transferase homologs
- 1 March 1994
- journal article
- research article
- Published by Wiley in Protein Science
- Vol. 3 (3) , 525-527
- https://doi.org/10.1002/pro.5560030318
Abstract
Although macrophage migration inhibitory factor (MIF) proteins conjugate glutathione, sequence analysis does not support their homology to other glutathione transferases. Glutathione transferases are not detected with MIF proteins in searches of protein sequence databases, and MIF proteins do not share significant sequence similarity with glutathione transferases. Homology cannot be demonstrated by multiple sequence alignment or evolutionary tree construction; such methods assume that the proteins being analyzed are homologous.Keywords
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