Relationship between methamphetamine levels in the marrow and serum.
- 1 January 1987
- journal article
- research article
- Published by Pharmaceutical Society of Japan in Eisei kagaku
- Vol. 33 (2) , 136-139
- https://doi.org/10.1248/jhs1956.33.136
Abstract
By determining methamphetamine levels in rat femora marrow by gas chromatography-mass spectrometry (GC-MS), an investigation was undertaken to estimate its serum concentration. The concentration was attained to its maximum at 5 min in the serum and at 60 min in bone marrow after administration. The ratio of serum to marrow levels at 45 to 120 min after administration was 0.140 .+-. 0.021. At doses between 1-10 mg/kg the average ratio of serum to marrow methamphetamine 60 min after administration was 0.111 .+-. 0.044 with a correlation coefficient of 0.837.This publication has 0 references indexed in Scilit: