Tissue and Serum Aldolase of Rats with Primary Hepatoma

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Abstract
1) Tissue and serum aldolase of normal and tumor-bearing (primary hepatoma and transplanted sarcoma) Osborne-Mendel rats were studied. Blood for aldolase assay was drawn from portal vein and inferior vena cava of hepatoma-bearing and control rats, from tumor vein and heart of sarcoma-bearing rats and also from heart of control rats. 2) Control rats had an average serum aldolase value of 70 units each for portal vein, vena cava and heart blood. Serum aldolase values of sarcoma-bearing rats were about 3 times and those of hepatoma-bearing rats about 8 times the values for control rats. These values averaged 375 units for blood entering tumorous liver and 540 units for blood leaving it. Serum aldolase values for heart blood averaged 176 while that for sarcoma-vein blood of the same rats averaged 194 units. Average aldolase value for normal liver, hepatoma, hepatoma-free liver, sarcoma and sarcoma-rat liver were 14,400, 12,400, 9,600, 7,700 and 9,100 units, respectively. Liver aldolase levels for tumor-bearing rats were about 35% lower than those for control rats. Aldolase values for necrotic areas of tumors were similar to serum aldolase values for respective rats.